CCBMA Clinical Practice Exam

Subcutaneous injections deliver medication into the loose connective tissue under the skin, which has limited capacity and blood flow compared with muscle. Because of that, large volumes can stretch the tissue, cause more pain, and lead to slower or inconsistent absorption. The practical upper limit to minimize tissue distortion and improve comfort and absorption is about 2 mL per site. In practice, smaller volumes (often 0.5 to 1 mL) are common, and if more drug is needed, use multiple sites or consider a different route if appropriate.